Intolerance and its terrible effects are examined in four historical eras. In ancient Babylon, a mountain girl is caught up in the religious rivalry that leads to the city's downfall. In Judea, the hypocritical Pharisees condemn Jesus Christ. In 1572 Paris, unaware of the impending St. Bartholomew's Day Massacre, two young Huguenots prepare for marriage. Finally, in modern America, social reformers destroy the lives of a young woman and her beloved.

When Selby arrives as the new ranch owner, he is assumed to be just another cowboy attracted to Ann Hepburn so he takes a job as a dude cowhand. He learns cattle are being rustled and he suspects the boss Sam Hepburn. But Hepburn suspects the foreman Hyslip and when he catches him with the goods, Hyslip shoots him. Hyslip then blames the new dude, and sends his men out to kill him.